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論文実績

NGS解析

Short Insertion and Deletion Discoveries via Whole-Genome Sequencing of 101 Thoroughbred Racehorses

T. Tozaki, A. Ohnuma, M. Kikuchi, T. Ishige, H. Kakoi, K. Hirota, Y. Takahashi and S. Nagata
Genes 2023, 14(3), 638; https://doi.org/10.3390/genes14030638

Detection of Indiscriminate Genetic Manipulation in Thoroughbred Racehorses by Targeted Resequencing for Gene-Doping Control

T. Tozaki,A. Ohnuma,K. Nakamura,K. Hano,M. Takasu,Y. Takahashi,N. Tamura,F. Sato,K. Shimizu,M. Kikuchi,T. Ishige,H. Kakoi,K. Hirota,N. A. Hamilton, S. Nagata
Genes 2022, 13(9), 1589; https://doi.org/10.3390/genes13091589
PMID: 36140757[PubMed – indexed for MEDLINE], PMCID: PMC9498419

Simulated validation of intron-less transgene detection using DELLY for gene-doping control in horse sports

T Tozaki, A Ohnuma, M Kikuchi, T Ishige, H Kakoi, K Hirota, K Kusano, S Nagata
Anim Genet. 2021 Oct;52(5):759-761. doi: 10.1111/age.13127. Epub 2021 Aug 2.
PMID: 34339052[PubMed – indexed for MEDLINE]

Rare and common variant discovery by whole-genome sequencing of 101 Thoroughbred racehorses

T. Tozaki, A. Ohnuma, M. Kikuchi, T. Ishige, H. Kakoi, K. Hirota, K. Kusano, S. Nagata
Sci Rep. 2021 Aug 6;11(1):16057. doi: 10.1038/s41598-021-95669-1.
PMID: 34362995[PubMed – indexed for MEDLINE], PMCID: PMC8346562

DMP-1 promoter-associated antisense strand non-coding RNA, panRNA-DMP-1, physically associates with EGFR to repress EGF-induced squamous cell carcinoma migration.

Suzuki S, Yuan H, Hirata-Tsuchiya S, Yoshida K, Sato A, Nemoto E, Shiba H, Yamada S
Mol. Cell. Biochem. 2021 Apr;476(4):1673-1690. doi: 10.1007/s11010-020-04046-5. Epub 2021 Jan 9.
PMID: 33420898 [PubMed – indexed for MEDLINE]

Detection of non-targeted transgenes by whole-genome resequencing for gene-doping control.

Tozaki T, Ohnuma A, Takasu M, Nakamura K, Kikuchi M, Ishige T, Kakoi H, Hirora KI, Tamura N, Kusano K, Nagata SI
Gene Ther. 2021 Apr;28(3-4):199-205. doi: 10.1038/s41434-020-00185-y. Epub 2020 Aug 7.
PMID: 32770095 [PubMed – indexed for MEDLINE]

Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue.

Sunagawa Y, Yamada S, Sonohara F, Kurimoto K, Tanaka N, Suzuki Y, Inokawa Y, Takami H, Hayashi M, Kanda M, Tanaka C, Nakayama G, Koike M, Kodera Y
Sci. Rep. 2021 Mar 16;11(1):6016. doi: 10.1038/s41598-021-85237-y.
PMID: 33727578 [PubMed – indexed for MEDLINE], PMCID: PMC7971023

Exome of Radiation-induced Rat Mammary Carcinoma Shows Copy-number Losses and Mutations in Human-relevant Cancer Genes.

Moriyama H, Daino K, Ishikawa A, Imaoka T, Nishimura M, Nishimura Y, Takabatake M, Morioka T, Inoue K, Fukushi M, Shimada Y, Kakinuma S
Anticancer Res. 2021 Jan;41(1):55-70. doi: 10.21873/anticanres.14751.
PMID: 33419799 [PubMed – indexed for MEDLINE]

Whole-genome resequencing using genomic DNA extracted from horsehair roots for gene-doping control in horse sports.

Tozaki T, Ohnuma A, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Hamilton NA, Kusano K, Nagata SI
J. Equine. Sci. 2020 Dec;31(4):75-83. doi: 10.1294/jes.31.75. Epub 2020 Dec 18.
PMID: 33376443 [PubMed – indexed for MEDLINE], PMCID: PMC7750640

Detection of somatic TP53 mutation in surgically resected small-cell lung cancer by targeted exome sequencing: association with longer relapse-free survival.

Yokouchi H, Nishihara H, Harada T, Yamazaki S, Kikuchi H, Oizumi S, Uramoto H, Tanaka F, Harada M, Akie K, Sugaya F, Fujita Y, Takamura K, Kojima T, Higuchi M, Honjo O, Minami Y, Watanabe N, Nishimura M, Suzuki H, Dosaka-Akita H, Isobe H
Heliyon 2020 Jul 13;6(7):e04439. doi: 10.1016/j.heliyon.2020.e04439. eCollection 2020 Jul.
PMID: 32685741 [PubMed – indexed for MEDLINE], PMCID: PMC7358392

Functional Expression of the P2X7 ATP Receptor Requires Eros.

Ryoden Y, Fujii T, Segawa K, Nagata S
J. Immunol. 2020 Feb 1;204(3):559-568. doi: 10.4049/jimmunol.1900448. Epub 2019 Dec 20.
PMID: 31862710 [PubMed – indexed for MEDLINE]

A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer’s disease.

Asanomi Y, Shigemizu D, Miyashita A, Mitsumori R, Mori T, Hara N, Ito K, Niida S, Ikeuchi T, Ozaki K
Mol. Med. 2019 Jun 20;25(1):20. doi: 10.1186/s10020-019-0090-5.
PMID: 31216982 [PubMed – indexed for MEDLINE], PMCID: PMC6585023

Mutational landscape of T-cell lymphoma in mice lacking the DNA mismatch repair gene Mlh1: no synergism with ionizing radiation.

Daino K, Ishikawa A, Suga T, Amasaki Y, Kodama Y, Shang Y, Hirano-Sakairi S, Nishimura M, Nakata A, Yoshida M, Imai T, Shimada Y, Kakinuma S
Carcinogenesis 2019 Apr 29;40(2):216-224. doi: 10.1093/carcin/bgz013.
PMID: 30721949 [PubMed – indexed for MEDLINE]

High genetic stability in MDCK-SIAT1 passaged human influenza viruses.

Matsumoto S, Chong Y, Kang D, Ikematsu H
J Infect Chemother. 2019 Mar;25(3):222-224. doi: 10.1016/j.jiac.2018.08.012. Epub 2018 Sep 18.
PMID: 30241880 [PubMed – indexed for MEDLINE]

Consecutive influenza surveillance of neuraminidase mutations and neuraminidase inhibitor resistance in Japan.

Chong Y, Matsumoto S, Kang D, Ikematsu H
Influenza Other Respir. Viruses 2019 Mar;13(2):115-122. doi: 10.1111/irv.12624. Epub 2019 Jan 9.
PMID: 30548432 [PubMed – indexed for MEDLINE], PMCID:PMC6379637

Phospholipid flippases enable precursor B cells to flee engulfment by macrophages.

Segawa K, Yanagihashi Y, Yamada K, Suzuki C, Uchiyama Y, Nagata S
Proc. Natl. Acad. Sci. USA 2018 Nov 27;115 (48) 12212-12217; doi: 10.1073/pnas.1814323115. Epub 2018 Oct 24.
PMID: 30355768 [PubMed – indexed for MEDLINE], PMCID: PMC6275493

Spread of predominant neuraminidase and hemagglutinin co-mutations in the influenza A/H3N2 virus genome.

Chong Y, Ikematsu H
J. Infect. Chemother. 2018 Mar;24(3):193-198. doi: 10.1016/j.jiac.2017.10.010. Epub 2017 Nov 4.
PMID: 29113775 [PubMed – indexed for MEDLINE]

The CDC50A extracellular domain is required for forming a functional complex with and chaperoning phospholipid flippases to the plasma membrane.

Segawa K, Kurata S, Nagata S
J. Bio. Chem. 2017 Dec 24.pii:jbc.RA117.000289. doi: 10.1074/jbc.RA117.000289.
PMID: 29276178 [PubMed – indexed for MEDLINE]

Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model.

Satou Y, Katsuya H, Fukuda A, Misawa N, Ito J, Uchiyama Y, Miyazato P, Islam S, Fassati A, Melamed A, Bangham CRM, Koyanagi Y, Sato K
Sci. Rep. 2017 Jul 31;7(1):6931. doi: 10.1038/s41598-017-07307-4
PMID: 28761140 [PubMed – indexed for MEDLINE], PMCID: PMC5537293

Pediatric-onset Chronic Nonspecific Multiple Ulcers of Small Intestine: A Nationwide Survey and Genetic Study in Japan.

Uchida K, Nakajima A, Ushijima K, Ida S, Seki Y, Kakuta F, Abukawa D, Tsukahara H, Maisawa SI, Inoue M, Araki T, Umeno J, Matsumoto T, Taguchi T
J. Pediatr. Gastroenterol. Nutr. 2017 Apr;64(4):565-568. doi: 10.1097/MPG.0000000000001321.
PMID: 27467110 [PubMed – indexed for MEDLINE]

Effect of seasonal vaccination on the selection of influenza A/H3N2 epidemic variants.

Chong Y, Ikematsu H
Vaccine 2017 Jan 5;35(2):255-263. doi: 10.1016/j.vaccine.2016.11.084. Epub 2016 Dec 3.
PMID: 27919631 [PubMed – indexed for MEDLINE]

Clinical impact of targeted amplicon sequencing for meningioma as a practical clinical-sequencing system.

Yuzawa S, Nishihara H, Yamaguchi S, Mohri H, Wang L, Kimura T, Tsuda M, Tanino M, Kobayashi H, Terasaka S, Houkin K, Sato N, Tanaka S
Mod. Pathol. 2016 Jul;29(7):708-716. doi:10.1038/modpathol.2016.81. Epub 2016 Apr 22.
PMID: 27102344 [PubMed – indexed for MEDLINE]

A Hereditary Enteropathy Caused by Mutations in the SLCO2A1 Gene, Encoding a Prostaglandin Transporter.

Umeno J, Hisamatsu T, Esaki M, Hirano A, Kubokura N, Asano K, Kochi S, Yanai S, Fuyuno Y, Shimamura K, Hosoe N, Ogata H, Watanabe T, Aoyagi K, Ooi H, Watanabe K, Yasukawa S, Hirai F, Matsui T, Iida M, Yao T, Hibi T, Kosaki K, Kanai T, Kitazono T, Matsumoto T
PLOS Genet. 2015 Nov 5;11(11):e1005581. doi: 10.1371/journal.pgen.1005581. eCollection 2015 Nov.

PMID: 26539716 [PubMed – indexed for MEDLINE]

MicroRNA-Seq Data Analysis Pipeline to Identify Blood Biomarkers for Alzheimer’s Disease from Public Data.

Satoh J, Kino Y, Niida S
Biomark. Insights 2015 Apr 15;10:21-31. doi: 10.4137/BMI.S25132. eCollection 2015.

PMID: 25922570 [PubMed – indexed for MEDLINE]

Simulation and estimation of gene number in a biological pathway using almost complete saturation mutagenesis screening of haploid mouse cells.

Tokunaga M, Kokubu C, Maeda Y, Sese J, Horie K, Sugimoto N, Kinoshita T, Yusa K, Takeda J
BMC Genomics 2014 Nov 24;15:1016. doi: 10.1186/1471-2164-15-1016.

PMID: 25418962 [PubMed – indexed for MEDLINE]

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure.

Segawa K, Kurata S, Yanagihashi Y, Brummelkamp TR, Matsuda F, Nagata S
Science 2014 Jun 6;344(6188):1164-8. doi: 10.1126/science.1252809.
PMID: 24904167 [PubMed – indexed for MEDLINE]

Global Mapping of Cell Type-Specific Open Chromatin by FAIRE-seq Reveals the Regulatory Role of the NFI Family in Adipocyte.

Waki H, Nakamura M, Yamauchi T, Wakabayashi K, Yu J, Hirose-Yotsuya L, Take K, Sun W, Iwabu M, Okada-Iwabu M, Fujita T, Aoyama T, Tsutsumi S, Ueki K, Kodama T, Sakai J, Aburatani H, Kadowaki T
PLOS Genet. 2011 Oct;7(10):e1002311. doi: 10.1371/journal.pgen.1002311. Epub 2011 Oct 20.
PMID: 22028663 [PubMed – indexed for MEDLINE], PMCID: PMC3197683

GWAS解析

Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease.

Doi D, Magotani H, Kikuchi T, Ikeda M, Hiramatsu S, Yoshida K, Amano N, Nomura M, Umekage M, Morizane A, Takahashi J
Nat. Commun. 2020 Jul 6;11(1):3369. doi: 10.1038/s41467-020-17165-w.
PMID: 32632153 [PubMed – indexed for MEDLINE], PMCID: PMC7338530

A genome-wide association study for body weight in Japanese Thoroughbred racehorses clarifies candidate regions on chromosomes 3, 9, 15, and 18.

Tozaki T, Kikuchi M, Kakoi H, Hirota KI, Nagata SI.
Equine Sci. 2017;28(4):127-134. doi: 10.1294/jes.28.127. Epub 2017 Dec 16.
PMID: 29270069 [PubMed – indexed for MEDLINE], PMCID: PMC5735309

Impact of four loci on serum tamsulosin hydrochloride concentration.

Takata R, Matsuda K, Sugimura J, Obara W, Fujioka T, Okihara K, Takaha N, Miki T, Ashida S, Inoue K, Tanikawa C, Shuin T, Sasaki S, Kojima Y, Kohri K, Kubo M, Yamaguchi M, Ohnishi Y, Nakamura Y.
J. Hum. Genet. 2013 Jan;58(1):21-6. doi: 10.1038/jhg.2012.126. Epub 2012 Nov 15.
PMID: 23151678 [PubMed – indexed for MEDLINE]

A genome-wide association study identifies RNF213 as the first Moyamoya disease gene.

Kamada F, Aoki Y, Narisawa A, Abe Y, Komatsuzaki S, Kikuchi A, Kanno J, Niihori T, Ono M, Ishii N, Owada Y, Fujimura M, Mashimo Y, Suzuki Y, Hata A, Tsuchiya S, Tominaga T, Matsubara Y, Kure S.
J. Hum. Genet. 2011 Jan;56(1):34-40. doi: 10.1038/jhg.2010.132. Epub 2010 Nov 4.
PMID: 21048783 [PubMed – indexed for MEDLINE]

A trans-ethnic genetic study of rheumatoid arthritis identified FCGR2A as a candidate common risk factor in Japanese and European populations.

Meziani R, Yamada R, Takahashi M, Ohigashi K, Morinobu A, Terao C, Hiratani H, Ohmura K, Yamaguchi M, Nomura T, Vasilescu A, Kokubo M, Renault V, Hirosawa K, Ratanajaraya C, Heath S, Mimori T, Sakaguchi S, Lathrop M, Melchers I, Kumagai S, Matsuda F.
Mod. Rheumatol. 2011 May 24.
PMID: 21607711 [PubMed – indexed for MEDLINE]

Replication study for the association between four Loci identified by a genome-wide association study on European American subjects with type 1 diabetes and susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes.

Maeda S, Araki S, Babazono T, Toyoda M, Umezono T, Kawai K, Imanishi M, Uzu T, Watada H, Suzuki D, Kashiwagi A, Iwamoto Y, Kaku K, Kawamori R, Nakamura Y.
Diabetes 2010 Aug;59(8):2075-9. doi: 10.2337/db10-0067. Epub 2010 May 11.
PMID: 20460425 [PubMed – indexed for MEDLINE], PMCID: PMC2911071

The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cells.

Wahlberg K, Jiang J, Rooks H, Jawaid K, Matsuda F, Yamaguchi M, Lathrop M, Thein SL, Best S.
Blood 2009 Jun 15. [Epub ahead of print]
PMID: 19528534 [PubMed – indexed for MEDLINE]

A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

Menzel S, Garner C, Gut I, Matsuda F, Yamaguchi M, Heath S, Foglio M, Zelenika D, Boland A, Rooks H, Best S, Spector TD, Farrall M, Lathrop M, Thein SL.
Nat. Genet. 2007 Oct;39(10):1197-9. Epub 2007 Sep 2.
PMID: 17767159 [PubMed – indexed for MEDLINE]

Intergenic variants of HBS1L-MYB are responsible for a major quantitative trait locus on chromosome 6q23 influencing fetal hemoglobin levels in adults.

Thein SL, Menzel S, Peng X, Best S, Jiang J, Close J, Silver N, Gerovasilli A, Ping C, Yamaguchi M, Wahlberg K, Ulug P, Spector TD, Garner C, Matsuda F, Farrall M, Lathrop M.
Proc. Natl. Acad. Sci. USA 2007 Jul 3;104(27):11346-51. Epub 2007 Jun 25.
PMID: 17592125 [PubMed – indexed for MEDLINE]

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